diff --git a/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.js b/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.js
index 6ba2f0ac051..7f406e5d8c3 100644
--- a/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.js
+++ b/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.js
@@ -262,6 +262,11 @@ frappe.ui.form.on("Stock Reconciliation Item", {
 
 	qty: function (frm, cdt, cdn) {
 		frm.events.set_amount_quantity(frm, cdt, cdn);
+
+		let row = locals[cdt][cdn];
+		if (!row.qty) {
+			frappe.model.set_value(cdt, cdn, "serial_no", "");
+		}
 	},
 
 	valuation_rate: function (frm, cdt, cdn) {
diff --git a/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.py b/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.py
index adc67c6bb44..d1b81aa2ebe 100644
--- a/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.py
+++ b/erpnext/stock/doctype/stock_reconciliation/stock_reconciliation.py
@@ -250,7 +250,7 @@ class StockReconciliation(StockController):
 			validate_is_stock_item(item_code, item.is_stock_item)
 
 			# item should not be serialized
-			if item.has_serial_no and not row.serial_no and not item.serial_no_series:
+			if item.has_serial_no and row.qty and not row.serial_no and not item.serial_no_series:
 				raise frappe.ValidationError(
 					_("Serial no(s) required for serialized item {0}").format(item_code)
 				)